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Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.

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Org Biomol Chem. Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. N Engl J Med. Urinary excretion of inositol phosphoglycan P-type in gestational diabetes mellitus. Diabet Med. Altered D-chiro-inositol urinary clearance in women with polycystic ovary syndrome.


Diabetes Care. Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism. Hum Reprod. Relationships between urinary inositol excretions and whole-body glucose tolerance and skeletal muscle insulin receptor phosphorylation.

Urinary myo-inositol-to-chiro-inositol ratios and insulin resistance. Soft gelatin capsules softgels. J Pharm Sci.

Alterations of Sphingolipid Metabolism in Different Types of Polycystic Ovary Syndrome

Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use. Expert Opin Drug Deliv. Myo-inositol in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol. D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance. Int J Exp Diabetes Res. Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls.

Biochem Biophys Res Commun. Detection of orally administered inositol stereoisomers in mouse blood plasma and their effects on translocation of glucose transporter 4 in skeletal muscle cells. J Agric Food Chem. Chronic dietary inositol enhances locomotor activity and brain inositol levels in rats. Psychopharmacology Berl. High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium.

Pharmacol Biochem Behav. Differential uptake of myo-inositol in vivo into rat brain areas. Eur Neuropsychopharmacol. Myo-inositol transport through the blood-brain barrier.

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Neurochem Res. Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures. Inositol treatment raises CSF inositol levels. Brain Res. Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder.

Polycystic ovarian syndrome (PCOS)

Am J Psychiatry. Modulation of protein kinase C isozymes and substrates by lithium: the role of myo-inositol. Double-blind, controlled trial of inositol treatment of depression. Follow-up and relapse analysis of an inositol study of depression. Isr J Psychiatry Relat Sci. Effect of inositol on bulimia nervosa and binge eating. Int J Eat Disord.

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Inositol addition does not improve depression in SSRI treatment failures. J Neural Transm.

Combination of inositol and serotonin reuptake inhibitors in the treatment of depression. Biol Psychiatry. Premenstrual dysphoric disorder--review of actual findings about mental disorders related to menstrual cycle and possibilities of their therapy. Prague Med Rep. Myo-inositol has no beneficial effect on premenstrual dysphoric disorder.

World J Biol Psychiatry.

Inositol Supplement - Science-based Review on Benefits, Dosage, Side Effects | vitourbill.tk

Inositol as an add-on treatment for bipolar depression. Adjuvant use of nutritional and herbal medicines with antidepressants, mood stabilizers and benzodiazepines. J Psychiatr Res. Mood disorders and complementary and alternative medicine: a literature review. Neuropsychiatr Dis Treat. Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone.

Inositol has behavioral effects with adaptation after chronic administration. Chronic epi-inositol has an anxiolytic-like effect in the plus-maze model in rats.

Int J Neuropsychopharmacol. The anxiolytic effect of chronic inositol depends on the baseline level of anxiety.

Polycystic Ovarian Syndrome

Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharmacol. Acute inositol does not attenuate m-CPP-induced anxiety, mydriasis and endocrine effects in panic disorder. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder.

Inositol treatment of post-traumatic stress disorder. CSF inositol in schizophrenia and high-dose inositol treatment of schizophrenia. Lack of effect of inositol treatment in chronic schizophrenia. Inositol treatment of obsessive-compulsive disorder. The effect of peripheral inositol injection on rat motor activity models of depression. Isr J Med Sci. Lack of effect of 6 g inositol treatment of post-ECT cognitive function in humans.

Identification of Scyllo-inositol in proton NMR spectra of human brain in vivo. J Comput Assist Tomogr. Identification of a high concentration of scyllo-inositol in the brain of a healthy human subject using 1H- and 13C-NMR. Magn Reson Med. Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology. J Mol Med Berl.